Mafoprazine

Veterinary antipsychotic From Wikipedia, the free encyclopedia

Mafoprazine is an antipsychotic of the phenylpiperazine class which is used in veterinary medicine.[1] Intramuscular injections of mafoprazine mesylate are used for the sedation of pigs either on its own,[2] or in combination with sodium pentobarbital[3] or thiopental.[4]

Trade namesMafropan
AHFS/Drugs.comMonograph
CAS Number
PubChem CID
Quick facts Clinical data, Trade names ...
Mafoprazine
Clinical data
Trade namesMafropan
AHFS/Drugs.comMonograph
Identifiers
  • N-[4-[3-[4-(2-fluorophenyl)piperazin-1-yl]propoxy]-3-methoxyphenyl]acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H28FN3O3
Molar mass401.482 g·mol−1
3D model (JSmol)
  • COC1=C(OCCCN2CCN(CC2)C3=C(F)C=CC=C3)C=CC(NC(C)=O)=C1
  • InChI=1S/C22H28FN3O3/c1-17(27)24-18-8-9-21(22(16-18)28-2)29-15-5-10-25-11-13-26(14-12-25)20-7-4-3-6-19(20)23/h3-4,6-9,16H,5,10-15H2,1-2H3,(H,24,27) checkY
  • Key:PHOCQBYGUQPMIB-UHFFFAOYSA-N checkY
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Pharmacology

More information Site, Ki (nM) ...
Mafoprazine
Site Ki (nM) Species Ref
D2 10.7 Rat [5][6]
α1 12.7 Rat [5][6]
α2 101.0 Rat [5][6]
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It demonstrates activity as a D2 dopamine receptor antagonist, an α1 adrenergic receptor antagonist, and an α2 adrenergic receptor agonist.[5]

The affinity of mafoprazine for D2 dopamine receptors is 6 and 16 times lower than that of chlorpromazine and haloperidol, respectively, but 2 times higher than that of azaperone.[5]

The Ki for various receptors was determined using rat neuronal receptor binding assays.[citation needed]

History

Mafoprazine was first synthesized in 1988.[5] It is sold as Mafropan® by DS Pharma Animal Health Co. Ltd., Osaka, Japan.

References

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