Maneb

Exposure to maneb can occur when breathed in; it can irritate the eyes, nose, and throat as well as cause headache, fatigue, nervousness, dizziness, seizures and even unconsciousness. Prolonged or long-term exposure may interfere with the function of the thyroid. Exposure to maneb is also shown to induce a Parkinson's disease like neurotoxicity in mice.^[2] The link between maneb and Parkinson's disease had been suspected since the early 2000s;^[3][4] but however, a 2022 review concluded that maneb, alongside other pesticides like MPTP, paraquat, and rotenone, play a prominent role in the development of the disease. More investigation is needed to investigate its underlying mechanism of action.^[5]

Manganese(II) ethylenebis(dithiocarbamate) of low ethylenethiourea (ETU) content is prepared by mixing disodium ethylenebis (dithiocarbamate) with formaldehyde in aqueous medium then mixing a water-soluble manganese(II) salt to precipitate the maneb. The product can be further formulated with a metal salt and also with paraformaldehyde. (See External links for the patent citation)

Maneb, is a broad spectrum fungicide that is extensively applied against a wide range of fungal pathogens affecting ornamental plants, food and feed crops. It can also be used to create a toxin-based animal model of Parkinson's disease, usually in primates.^[6][7]

Maneb was included in a pesticide ban proposed by the Swedish Chemicals Agency^[8] and approved by the European Parliament on January 13, 2009.^[9]

• Metam sodium - A related dithiocarbamate salt which is also used as a fungicide.
• Zineb - ethylene bis(dithiocarbamate) with zinc instead of manganese.
• Mancozeb - A common fungicide containing Zineb and Maneb.