Mantle zone
Part of a lymph node
From Wikipedia, the free encyclopedia
The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.[1]
| Mantle zone | |
|---|---|
Histology of a normal secondary lymphoid follicle, with yellow arrows pointing at the mantle zone. | |
| Anatomical terminology |
It is also known as the "corona".[2]
It contains transient lymphocytes.[3]
It is the location of the lymphoma in mantle cell lymphoma.
Pathology
Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.