Medrysone

Medrysone
Clinical data
Trade names	HMS, Medrocort, others
Other names	NSC-63278; Hydroxymethylprogesterone; Methylhydroxyprogesterone; Hydroxymesterone; 6α-Methyl-11β-hydroxyprogesterone; 6α-Methyl-11β-hydroxypregn-4-ene-3,20-dione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a606003
Routes of; administration	Eye drops
ATC code	S01BA08 (WHO) ;
Legal status
Legal status	US: Discontinued;
Identifiers
	IUPAC name (6S,8S,9S,10R,11S,13R,14S,17S)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,; 11,12,14,15,16,17- dodecahydrocyclopenta[a] phenanthren-3-one;
CAS Number	2668-66-8 ;
PubChem CID	247839;
IUPHAR/BPS	7086;
DrugBank	DB00253 ;
ChemSpider	216968 ;
UNII	D2UFC189XF;
KEGG	D02289 ;
ChEMBL	ChEMBL1201173 ;
CompTox Dashboard (EPA)	DTXSID6045371 ;
ECHA InfoCard	100.018.371
Chemical and physical data
Formula	C22H32O3
Molar mass	344.495 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C;
	InChI InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 ; Key:GZENKSODFLBBHQ-ILSZZQPISA-N ;
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Medrysone (INN, USAN; brand names HMS, Medrocort, others; former developmental code NSC-63278; also known as hydroxymethylprogesterone, methylhydroxyprogesterone, hydroxymesterone, 6α-methyl-11β-hydroxyprogesterone, or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione) is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases.^[1]^[2]^[3] It has been discontinued in the United States.^[4] Although it is very similar in structure to progesterone,^[5] neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.^[6]^[7]^[8]

Trade namesHMS, Medrocort, others

Other namesNSC-63278; Hydroxymethylprogesterone; Methylhydroxyprogesterone; Hydroxymesterone; 6α-Methyl-11β-hydroxyprogesterone; 6α-Methyl-11β-hydroxypregn-4-ene-3,20-dione

AHFS/Drugs.comMicromedex Detailed Consumer Information

MedlinePlusa606003

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