Mepindolol
Chemical compound
From Wikipedia, the free encyclopedia
Mepindolol (Betagon) is a non-selective beta blocker. It is used to treat glaucoma.[1]
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| ECHA InfoCard | 100.041.650 |
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| Formula | C15H22N2O2 |
| Molar mass | 262.353 g·mol−1 |
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| Chirality | Racemic mixture |
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Synthesis
The first reported synthesis of mepindolol in 1971 used 4-hydroxy-2-methylindole {9) with epichlorohydrin and then isopropylamine to add the sidechain which was known to produce beta blockers, by analogy with drugs discovered by Imperial Chemical Industries, such as propanolol.[2] The requisite intermediate was synthesized in a multi-step procedure from 4-benzyloxyindole-2-carboxylic acid (1) which was converted into (9) by conventional chemistry.[3][4]
