Metazosin

Chemical compound From Wikipedia, the free encyclopedia

Metazosin is an antihypertensive α1-adrenergic receptor antagonist.[1][2]

Quick facts Names, Identifiers ...
Metazosin
Names
IUPAC name
1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-methoxypropan-1-one
Other names
Kenosin
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C18H25N5O4/c1-11(25-2)17(24)22-5-7-23(8-6-22)18-20-13-10-15(27-4)14(26-3)9-12(13)16(19)21-18/h9-11H,5-8H2,1-4H3,(H2,19,20,21)
    Key: YEOTYALSMRNXLJ-UHFFFAOYSA-N
  • CC(C(=O)N1CCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC)OC
Properties
C18H25N5O4
Molar mass 375.429 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Synthesis

The amide (3) is formed when piperazine is reacted with 2-methoxypropionylchloride (2). Metazosin is the product when this intermediate is reacted with the substituted quinazoline (4).[3][4]

References

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