Methoxyketamine

Methoxyketamine or 2-MeO-2-deschloroketamine is a designer drug of the arylcyclohexylamine class first reported in 1963.^[1] It is an analog of ketamine in which the chlorine atom has been replaced with a methoxy group. Its synthesis by rearrangement of an amino ketone has been reported.^[2] As an arylcyclohexylamine, methoxyketamine most likely functions as an NMDA receptor antagonist. It produces sedative, hallucinogenic, and (at high doses) anesthetic effects, but with a lower potency than ketamine itself.

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Methoxyketamine

Names
IUPAC name 2-(2-Methoxyphenyl)-2-(methylamino)cyclohexanone
Identifiers
CAS Number	7063-51-6 Y 6728-62-7 (HCl) Y
3D model (JSmol)	Interactive image
ChemSpider	27470964
PubChem CID	57483650
UNII	U4I8JIS24N Y 2OVB5UO35R (HCl) Y
CompTox Dashboard (EPA)	DTXSID30990849
InChI InChI=1S/C14H19NO2/c1-15-14(10-6-5-9-13(14)16)11-7-3-4-8-12(11)17-2/h3-4,7-8,15H,5-6,9-10H2,1-2H3 Key: OYAUVHORXFUVAJ-UHFFFAOYSA-N InChI=1/C14H19NO2/c1-15-14(10-6-5-9-13(14)16)11-7-3-4-8-12(11)17-2/h3-4,7-8,15H,5-6,9-10H2,1-2H3 Key: OYAUVHORXFUVAJ-UHFFFAOYAM
SMILES CNC1(CCCCC1=O)c2ccccc2OC
Properties
Chemical formula	C14H19NO2
Molar mass	233.311 g·mol−1
Pharmacology
Legal status	UK: Class B
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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