Metonitazene

Legal status

• BR: Class F1 (Prohibited narcotics)
• DE: Anlage II (Authorized trade only, not prescriptible)
• UK: Class A
• US: Schedule I
• Illegal in Sweden^[1]

CAS Number

• 14680-51-4 ^Y

PubChem CID

• 53316366

ChemSpider

• 81407756

Metonitazene

Legal status
Legal status	BR: Class F1 (Prohibited narcotics) DE: Anlage II (Authorized trade only, not prescriptible) UK: Class A US: Schedule I Illegal in Sweden[1]
Identifiers
IUPAC name 2-[2-(4-Methoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine
CAS Number	14680-51-4 Y
PubChem CID	53316366
ChemSpider	81407756
UNII	A7FF4K4CWB
KEGG	C22727 Y
ChEBI	CHEBI:234362
CompTox Dashboard (EPA)	DTXSID901336445
Chemical and physical data
Formula	C21H26N4O3
Molar mass	382.464 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OC
InChI InChI=1S/C21H26N4O3/c1-4-23(5-2)12-13-24-20-11-8-17(25(26)27)15-19(20)22-21(24)14-16-6-9-18(28-3)10-7-16/h6-11,15H,4-5,12-14H2,1-3H3 Key:HNGZTLMRQTVPBH-UHFFFAOYSA-N

Metonitazene is an analgesic compound related to etonitazene,^[2][3] which was first reported in 1957,^[4] and has been shown to have approximately 100 times the potency of morphine by central routes of administration,^[5][6] but if used orally it has been shown to have approximately 10 times the potency of morphine.^[7]

Its effects are similar to other opioids such as fentanyl and heroin, including analgesia, euphoria, and sleepiness.^[7][8] Adverse effects include vomiting, and respiratory depression that can potentially be fatal.^[9] Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy. It is instead commonly used in the illicit manufacture of counterfeit oxycodone opioid pills.^[10]