MiR-150
Family of microRNA precursors found in mammals
From Wikipedia, the free encyclopedia
miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
| miR-150 | |
|---|---|
Conserved secondary structure of miR-150 microRNA precursor | |
| Identifiers | |
| Symbol | miR-150 |
| Alt. Symbols | MIR150 |
| Rfam | RF00767 |
| miRBase | MI0000479 |
| miRBase family | MIPF0000197 |
| NCBI Gene | 406942 |
| HGNC | 31537 |
| OMIM | 610566 |
| RefSeq | NR_029703 |
| Other data | |
| RNA type | miRNA |
| Domain | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 19 q13.33 |
| PDB structures | PDBe |
miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.[3][4] It is also thought to control B and T cell differentiation, alongside miR-155.[5][6]
Role in cancer
miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.[7] Moreover, recent studies indicated that miR-150 has an important role in leukemia, specifically in HTLV-1-mediated T-cell transformation.[8]
Applications
miR-150 levels in blood plasma can be indicative of early sepsis; it could have a future use therapeutically in treating the condition.[9] In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.[10]