Mir-145
Non-coding RNA in the species Homo sapiens
From Wikipedia, the free encyclopedia
In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[3]
| MIR145 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR145, microRNA 145, MIRN145, miR-145, miRNA145, MIRN145 microRNA, human | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611795; GeneCards: MIR145; OMA:MIR145 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| mir-145 | |
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 Conserved secondary structure of mir-145 | |
| Identifiers | |
| Symbol | mir-145 |
| Rfam | RF00675 |
| miRBase family | MIPF0000079 |
| Other data | |
| RNA type | microRNA |
| Domain | Eukaryota; |
| PDB structures | PDBe |
Targets
MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility.[4][5] Larsson et al.[6] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[7]
Role in cancer
miR-145 is hypothesised to be a tumor suppressor.[8] miR-145 has been shown to be down-regulated in breast cancer.[5] miR-145 is also involved in colon cancer[7][9][10] and acute myeloid leukemia.[11]