N-myc-interactor

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.[5][6][7]

AliasesNMI, N-myc and STAT interactor
End151,289,894 bp[1]
Quick facts NMI, Identifiers ...
NMI
Identifiers
AliasesNMI, N-myc and STAT interactor
External IDsOMIM: 603525; MGI: 1928368; HomoloGene: 3441; GeneCards: NMI; OMA:NMI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004688

NM_001141948
NM_001141949
NM_019401

RefSeq (protein)

NP_004679

NP_001135420
NP_001135421
NP_062274

Location (UCSC)Chr 2: 151.27 – 151.29 MbChr 2: 51.84 – 51.86 Mb
PubMed search[3][4]
Wikidata
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Function

NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[7]

Interactions

NMI (gene) has been shown to interact with BRCA1,[8] IFI35,[9] Myc,[8] and STAT5A,[6] and TUBA3C.[10]

References

Further reading

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