NADSYN1

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene.^[5][6]

AliasesNADSYN1, NAD synthetase 1, VCRL3

External IDsOMIM: 608285; MGI: 1926164; HomoloGene: 6098; GeneCards: NADSYN1; OMA:NADSYN1 - orthologs

Chr.Chromosome 11 (human)^[1]

End71,524,107 bp^[1]

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NADSYN1
Identifiers
Aliases	NADSYN1, NAD synthetase 1, VCRL3
External IDs	OMIM: 608285; MGI: 1926164; HomoloGene: 6098; GeneCards: NADSYN1; OMA:NADSYN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 71,453,109 bp[1] End 71,524,107 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 143,349,321 bp[2] End 143,376,586 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube granulocyte mucosa of transverse colon anterior pituitary minor salivary glands left ovary right lung skin of leg rectum body of stomach Top expressed in duodenum jejunum proximal tubule yolk sac right kidney left lobe of liver epithelium of small intestine colon ileum human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity protein binding ATP binding glutaminase activity NAD+ synthase (glutamine-hydrolyzing) activity Cellular component cytoplasm cytosol Biological process nitrogen compound metabolic process NAD metabolic process NAD biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55191 78914 Ensembl ENSG00000172890 ENSMUSG00000031090 UniProt Q6IA69 Q711T7 RefSeq (mRNA) NM_018161 NM_030221 NM_001308092 NM_001308095 RefSeq (protein) NP_060631 NP_001295024 NP_084497 Location (UCSC) Chr 11: 71.45 – 71.52 Mb Chr 7: 143.35 – 143.38 Mb PubMed search [3] [4]
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Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).^[6]