NAP1L4

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.^[5][6]

AliasesNAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4

External IDsOMIM: 601651; MGI: 1316687; HomoloGene: 133933; GeneCards: NAP1L4; OMA:NAP1L4 - orthologs

Chr.Chromosome 11 (human)^[1]

End2,992,377 bp^[1]

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NAP1L4
Identifiers
Aliases	NAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDs	OMIM: 601651; MGI: 1316687; HomoloGene: 133933; GeneCards: NAP1L4; OMA:NAP1L4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 2,944,431 bp[1] End 2,992,377 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.24 cM Start 143,513,579 bp[2] End 143,549,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence C1 segment Achilles tendon left testis right testis bone marrow cell sural nerve apex of heart epithelium of colon Top expressed in saccule ectoderm otic placode otic vesicle lens epithelium of lens medullary collecting duct superior cervical ganglion ventricular zone primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding RNA binding nucleosome binding Cellular component nucleus cytoplasm Biological process nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4676 17955 Ensembl ENSG00000205531 ENSG00000273562 ENSMUSG00000059119 UniProt Q99733 Q78ZA7 RefSeq (mRNA) NM_005969 NM_001285489 NM_001285490 NM_008672 RefSeq (protein) NP_005960 NP_001356304 NP_001356305 NP_001356306 NP_001356307 NP_001356308 NP_001356309 NP_001356310 NP_001356311 NP_001356312 NP_001356313 NP_001356314 NP_001356315 NP_001356317 NP_005960.1 NP_001272418 NP_001272419 NP_032698 Location (UCSC) Chr 11: 2.94 – 2.99 Mb Chr 7: 143.51 – 143.55 Mb PubMed search [3] [4]
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This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.^[6]