NAV1

Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene.^[5][6][7]

AliasesNAV1, POMFIL3, STEERIN1, UNC53H1, neuron navigator 1

External IDsOMIM: 611628; MGI: 2183683; HomoloGene: 10719; GeneCards: NAV1; OMA:NAV1 - orthologs

Chr.Chromosome 1 (human)^[1]

End201,826,969 bp^[1]

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NAV1
Identifiers
Aliases	NAV1, POMFIL3, STEERIN1, UNC53H1, neuron navigator 1
External IDs	OMIM: 611628; MGI: 2183683; HomoloGene: 10719; GeneCards: NAV1; OMA:NAV1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 201,622,885 bp[1] End 201,826,969 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,362,318 bp[2] End 135,615,843 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell external globus pallidus myocardium of left ventricle lateral nuclear group of thalamus saphenous vein pars reticulata Brodmann area 23 middle temporal gyrus inferior ganglion of vagus nerve pericardium Top expressed in Rostral migratory stream tail of embryo internal carotid artery genital tubercle external carotid artery ventromedial nucleus vas deferens subiculum ganglionic eminence anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule cytoskeleton microtubule cytoskeleton axon initial segment Biological process multicellular organism development cell differentiation neuron migration microtubule bundle formation nervous system development neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89796 215690 Ensembl ENSG00000134369 ENSMUSG00000009418 UniProt Q8NEY1 Q8CH77 RefSeq (mRNA) NM_001167738 NM_020443 NM_173437 RefSeq (protein) NP_001161210 NP_065176 NP_775613 Location (UCSC) Chr 1: 201.62 – 201.83 Mb Chr 1: 135.36 – 135.62 Mb PubMed search [3] [4]
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This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known.^[7]