NCOA6
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[5][6][7]
Function
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[7]
Interactions
NCOA6 has been shown to interact with:
- ASCL2[8] and
- Activating transcription factor 2,[9]
- Androgen receptor,[10]
- CREB-binding protein,[11][12]
- DNA-PKcs,[13]
- E2F1,[14]
- EP300,[13]
- Estrogen receptor alpha,[11][15]
- Estrogen receptor beta,[12][15]
- HBXIP,[16]
- HIST2H3C,[8]
- HSF1,[17]
- Ku70,[13][18]
- Ku80,[13][18]
- Liver X receptor beta,[12]
- MLL3,[8]
- RBBP5,[8]
- Retinoblastoma protein,[10]
- Retinoic acid receptor alpha,[11][12][13]
- Retinoid X receptor alpha,[11][12][15][16]
- Src,[8][11][12][19]
- TGS1,[20][21]
- TUBA4A,[8]
- TUBB,[8]
- Thyroid hormone receptor alpha,[11][19] and
- Thyroid hormone receptor beta.[11][12][13][15]