NDE1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.^[5]^[6]^[7]

AliasesNDE1, HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1, nudE neurodevelopment protein 1

External IDsOMIM: 609449; MGI: 1914453; HomoloGene: 32354; GeneCards: NDE1; OMA:NDE1 - orthologs

Chr.Chromosome 16 (human)^[1]

End15,734,691 bp^[1]

Quick facts Identifiers, Aliases ...

NDE1

Identifiers

NDE1, HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1, nudE neurodevelopment protein 1

External IDs

OMIM: 609449; MGI: 1914453; HomoloGene: 32354; GeneCards: NDE1; OMA:NDE1 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.11	Start	15,643,267 bp^[1]
Band	16p13.11	End	15,734,691 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 A1	Start	13,981,139 bp^[2]
Band	16\|16 A1	End	14,010,792 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

epithelium of colon

ventricular zone

corpus callosum

sural nerve

blood

monocyte

ganglionic eminence

bone marrow cell

tonsil

C1 segment

Top expressed in

ventricular zone

epiblast

maxillary prominence

primitive streak

mandibular prominence

hand

somite

thymus

abdominal wall

interventricular septum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein domain specific binding protein binding identical protein binding microtubule binding
Cellular component	cytoplasm cytosol centrosome membrane spindle spindle pole centrosome synapse chromosome microtubule organizing center cleavage furrow microtubule chromosome, centromeric region cytoskeleton kinetochore kinesin complex
Biological process	cell differentiation centrosome duplication establishment of chromosome localization neuron migration nervous system development cell division multicellular organism development G2/M transition of mitotic cell cycle establishment of mitotic spindle orientation cerebral cortex development neuroblast proliferation cell cycle forebrain development microtubule organizing center organization sister chromatid cohesion ciliary basal body-plasma membrane docking microtubule nucleation chromosome segregation mitotic centrosome separation cell migration vesicle transport along microtubule centrosome localization regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO

Species

Human

Mouse


54820


67203


ENSG00000072864 ENSG00000275911


ENSMUSG00000022678


Q9NXR1


Q9CZA6

RefSeq (mRNA)


NM_001143979 NM_017668


NM_001114085 NM_001285503 NM_001285504 NM_023317

RefSeq (protein)


NP_001137451 NP_060138


NP_001107557 NP_001272432 NP_001272433 NP_075806

Location (UCSC)

Chr 16: 15.64 – 15.73 Mb

Chr 16: 13.98 – 14.01 Mb

PubMed search

^[3]

^[4]

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Clinical significance

Mutations in NDE1 can cause severe and often fatal defects in fetal brain development.^[8]^[9]

References

Further reading

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