NDRG4

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.^[5][6][7]

AliasesNDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4

External IDsOMIM: 614463; MGI: 2384590; HomoloGene: 23228; GeneCards: NDRG4; OMA:NDRG4 - orthologs

Chr.Chromosome 16 (human)^[1]

End58,513,628 bp^[1]

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NDRG4
Identifiers
Aliases	NDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDs	OMIM: 614463; MGI: 2384590; HomoloGene: 23228; GeneCards: NDRG4; OMA:NDRG4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 58,462,846 bp[1] End 58,513,628 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D1 Start 95,676,980 bp[2] End 95,715,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pons lateral nuclear group of thalamus right frontal lobe prefrontal cortex apex of heart nucleus accumbens cerebellar vermis caudate nucleus dorsolateral prefrontal cortex Top expressed in olfactory tubercle medial dorsal nucleus medial geniculate nucleus pontine nuclei dorsal tegmental nucleus habenula medial vestibular nucleus lateral geniculate nucleus nucleus accumbens globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytosol basolateral plasma membrane cell projection membrane cytoplasm mitochondrion endoplasmic reticulum membrane Biological process visual learning negative regulation of platelet-derived growth factor receptor signaling pathway cell migration involved in heart development cell differentiation negative regulation of smooth muscle cell proliferation regulation of endocytic recycling negative regulation of smooth muscle cell migration cardiac muscle cell proliferation embryonic heart tube development heart looping cell growth vesicle docking positive regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development brain development signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65009 234593 Ensembl ENSG00000103034 ENSMUSG00000036564 UniProt Q9ULP0 Q8BTG7 RefSeq (mRNA) NM_001130487 NM_001242833 NM_001242834 NM_001242835 NM_001242836 NM_020465 NM_022910 NM_001363869 NM_001195006 NM_145602 RefSeq (protein) NP_001123959 NP_001229762 NP_001229763 NP_001229764 NP_001229765 NP_065198 NP_075061 NP_001350798 NP_001365261 NP_001365262 NP_001365263 NP_001365264 NP_001365265 NP_001365266 NP_001365267 NP_001365268 NP_001365269 NP_001365270 NP_001365271 NP_001365272 NP_001365273 NP_001365274 NP_001365275 NP_001365276 NP_001181935 NP_663577 NP_001359350 NP_001359352 NP_001359354 NP_001359355 NP_001359356 NP_001359357 NP_001359358 NP_001359359 NP_001359360 NP_001359361 NP_001359362 NP_001359363 NP_001359364 Location (UCSC) Chr 16: 58.46 – 58.51 Mb Chr 8: 95.68 – 95.72 Mb PubMed search [3] [4]
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This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[7]