NDUFAF8
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene.[4] This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.[5]
External IDsOMIM: 618461; MGI: 1913676; HomoloGene: 83602; GeneCards: NDUFAF8; OMA:NDUFAF8 - orthologs
| NDUFAF8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | NDUFAF8, C17orf89, NADH:ubiquinone oxidoreductase complex assembly factor 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 618461; MGI: 1913676; HomoloGene: 83602; GeneCards: NDUFAF8; OMA:NDUFAF8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Structure
The NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs.[4] The gene produces a 7.756 kDa protein composed of 74 amino acids.[6][7]
Function
The protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.[5]
Interaction
NDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.[5]
