NEDD1

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene^[5] and encodes the protein NEDD1.

AliasesNEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor

External IDsOMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs

Chr.Chromosome 12 (human)^[1]

End96,953,780 bp^[1]

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NEDD1
Identifiers
Aliases	NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDs	OMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 96,907,224 bp[1] End 96,953,780 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 92,520,608 bp[2] End 92,558,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of rectus abdominis biceps brachii sperm vastus lateralis muscle deltoid muscle buccal mucosa cell ventricular zone Skeletal muscle tissue of biceps brachii tibialis anterior muscle Top expressed in zygote secondary oocyte primary oocyte atrium right ventricle cardiac muscles digastric muscle genital tubercle myocardium of ventricle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule organizing center ciliary basal body centriole cytosol centrosome apical part of cell spindle pole pericentriolar material cytoskeleton Biological process cell division protein localization to centrosome cell cycle G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 121441 17997 Ensembl ENSG00000139350 ENSMUSG00000019988 UniProt Q8NHV4 P33215 RefSeq (mRNA) NM_001135175 NM_001135176 NM_001135177 NM_152905 NM_008682 RefSeq (protein) NP_001128647 NP_001128648 NP_001128649 NP_690869 NP_032708 Location (UCSC) Chr 12: 96.91 – 96.95 Mb Chr 10: 92.52 – 92.56 Mb PubMed search [3] [4]
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NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.