NELL2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Protein kinase C-binding protein NELL2 is a secreted glycoprotein that in humans is encoded by the NELL2 gene.[5] It is a homolog of Nel, which is a gene present in the neural tissues of chickens.[6]
| NELL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | NELL2, NRP2, neural EGFL like 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602320; MGI: 1858510; HomoloGene: 4488; GeneCards: NELL2; OMA:NELL2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a cytoplasmic protein that contains six epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.[5]
Function
NELL2 has been implicated to be involved in a variety of different functions including neuronal development, sperm maturation, cancer progression and bone development.[7][8][9][10]
NELL2 has been shown to have roles in neuronal polarization and axon growth.[11] NELL2 is a negative regulator of axon guidance in the SLIT-ROBO signalling pathway where it binds with the ROBO3/Rig-1 receptor.[12] It can also bind with ROBO2 under acidic conditions, where ROBO2 undergoes proteolytic cleavage.[8]
NELL2 expression has been linked to higher survival rates for female lung adenocarcinoma patients.[13]
