Sialidase-2

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.^[5][6][7]

AliasesNEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2

External IDsOMIM: 605528; MGI: 1344417; GeneCards: NEU2

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts NEU2, Identifiers ...

NEU2
Identifiers
Aliases	NEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2
External IDs	OMIM: 605528; MGI: 1344417; GeneCards: NEU2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SNT, 1SO7, 1VCU, 2F0Z, 2F10, 2F11, 2F12, 2F13, 2F24, 2F25, 2F26, 2F27, 2F28, 2F29, 4NC5, 4NCS
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.2.1.18 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,032,672 bp[1] End 233,035,057 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,437,611 bp[2] End 87,525,567 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skin of leg skin of abdomen connective tissue adipose tissue nervous system subcutaneous adipose tissue tibial nerve Top expressed in temporal muscle esophagus triceps brachii muscle right kidney sternocleidomastoid muscle respiratory epithelium olfactory epithelium vastus lateralis muscle lip muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity hydrolase activity, acting on glycosyl bonds protein binding exo-alpha-(2->3)-sialidase activity hydrolase activity exo-alpha-sialidase activity Cellular component cytoplasm membrane intracellular membrane-bounded organelle cytosol catalytic complex Biological process glycosphingolipid metabolic process lipid metabolism lipid catabolic process oligosaccharide catabolic process metabolism ganglioside catabolic process cellular oligosaccharide catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4759 23956 Ensembl ENSG00000115488 ENSMUSG00000079434 UniProt Q9Y3R4 Q9JMH3 RefSeq (mRNA) NM_005383 NM_001160163 NM_001160164 NM_001160165 NM_015750 RefSeq (protein) NP_005374 NP_001153635 NP_001153636 NP_001153637 NP_056565 Location (UCSC) Chr 2: 233.03 – 233.04 Mb Chr 1: 87.44 – 87.53 Mb PubMed search [3] [4]
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This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.^[7]