NFS1

Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the NFS1 gene.^[5][6][7]

AliasesNFS1, IscS, NIFS, HUSSY-08, NFS1 cysteine desulfurase, cysteine desulfurase, COXPD52

External IDsOMIM: 603485; MGI: 1316706; HomoloGene: 5463; GeneCards: NFS1; OMA:NFS1 - orthologs

Chr.Chromosome 20 (human)^[1]

End35,699,355 bp^[1]

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NFS1
Identifiers
Aliases	NFS1, IscS, NIFS, HUSSY-08, NFS1 cysteine desulfurase, cysteine desulfurase, COXPD52
External IDs	OMIM: 603485; MGI: 1316706; HomoloGene: 5463; GeneCards: NFS1; OMA:NFS1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,668,052 bp[1] End 35,699,355 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,965,559 bp[2] End 155,986,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver apex of heart right testis left testis mucosa of transverse colon right frontal lobe anterior cingulate cortex Top expressed in right kidney sternocleidomastoid muscle digastric muscle temporal muscle triceps brachii muscle muscle of thigh saccule human kidney otic placode proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein homodimerization activity iron-sulfur cluster binding metal ion binding protein binding catalytic activity pyridoxal phosphate binding cysteine desulfurase activity Cellular component cytosol nucleoplasm nucleus cytoplasm mitochondrion mitochondrial matrix Biological process molybdopterin cofactor biosynthetic process [2Fe-2S cluster assembly] Mo-molybdopterin cofactor biosynthetic process sulfur amino acid metabolic process small molecule metabolic process iron incorporation into metallo-sulfur cluster protein-containing complex assembly iron-sulfur cluster assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9054 18041 Ensembl ENSG00000244005 ENSMUSG00000027618 UniProt Q9Y697 Q9Z1J3 RefSeq (mRNA) NM_001198989 NM_021100 NM_181679 NM_010911 RefSeq (protein) NP_001185918 NP_066923 NP_035041 Location (UCSC) Chr 20: 35.67 – 35.7 Mb Chr 2: 155.97 – 155.99 Mb PubMed search [3] [4]
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Iron-sulfur clusters are required for the function of many cellular enzymes. The protein encoded by this gene supplies inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded protein belongs to the class-V family of pyridoxal phosphate-dependent aminotransferases.^[7]