NFX1

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.^[5][6][7]

AliasesNFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1

External IDsOMIM: 603255; MGI: 1921414; HomoloGene: 1875; GeneCards: NFX1; OMA:NFX1 - orthologs

Chr.Chromosome 9 (human)^[1]

End33,371,157 bp^[1]

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NFX1
Identifiers
Aliases	NFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
External IDs	OMIM: 603255; MGI: 1921414; HomoloGene: 1875; GeneCards: NFX1; OMA:NFX1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 33,290,512 bp[1] End 33,371,157 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 20.72 cM Start 40,970,906 bp[2] End 41,025,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell skin of hip tail of epididymis caput epididymis corpus epididymis endothelial cell right ventricle oral cavity skin of thigh biceps brachii Top expressed in cumulus cell primitive streak epiblast gastrula seminal vesicula dermis neural layer of retina hair follicle superior frontal gyrus aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific zinc ion binding ligase activity RNA polymerase II transcription regulatory region sequence-specific DNA binding metal ion binding nucleic acid binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transferase activity ubiquitin protein ligase activity Cellular component plasma membrane nucleolus nucleus cytosol Biological process inflammatory response viral process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of MHC class II biosynthetic process transcription, DNA-templated protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4799 74164 Ensembl ENSG00000086102 ENSMUSG00000028423 UniProt Q12986 B1AY10 RefSeq (mRNA) NM_002504 NM_147133 NM_147134 NM_001318758 NM_001290448 NM_001290449 NM_023739 RefSeq (protein) NP_001305687 NP_002495 NP_667345 NP_001277377 NP_001277378 NP_076228 Location (UCSC) Chr 9: 33.29 – 33.37 Mb Chr 4: 40.97 – 41.03 Mb PubMed search [3] [4]
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MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.^[8]