NFYB

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesNFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
Quick facts Available structures, PDB ...
NFYB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDsOMIM: 189904; MGI: 97317; HomoloGene: 38149; GeneCards: NFYB; OMA:NFYB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006166

NM_010914

RefSeq (protein)

NP_006157
NP_006157.1

NP_035044

Location (UCSC)Chr 12: 104.12 – 104.14 MbChr 10: 82.58 – 82.6 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[7]

Interactions

NFYB has been shown to interact with:

References

Further reading

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