NKX2-3

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.^[5][6][7]

AliasesNKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3

External IDsOMIM: 606727; MGI: 97348; HomoloGene: 17061; GeneCards: NKX2-3; OMA:NKX2-3 - orthologs

Chr.Chromosome 10 (human)^[1]

End99,536,524 bp^[1]

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NKX2-3
Identifiers
Aliases	NKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727; MGI: 97348; HomoloGene: 17061; GeneCards: NKX2-3; OMA:NKX2-3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 99,532,942 bp[1] End 99,536,524 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 36.67 cM Start 43,600,764 bp[2] End 43,604,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon spleen transverse colon duodenum sural nerve minor salivary glands jejunal mucosa mucosa of transverse colon cecum rectum Top expressed in Hindgut migratory enteric neural crest cell yolk sac Stomodeum buccopharyngeal membrane duodenum pharyngeal pouch ileum tongue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding molecular function DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity Cellular component nucleus cellular component Biological process leukocyte homeostasis CD4-positive, alpha-beta T cell differentiation post-embryonic digestive tract morphogenesis regulation of transcription, DNA-templated plasma cell differentiation spleen development post-embryonic development transcription, DNA-templated macrophage differentiation mucosa-associated lymphoid tissue development odontogenesis of dentin-containing tooth gland morphogenesis regulation of cell population proliferation immune response B cell differentiation Peyer's patch development digestive tract development lymph node development triglyceride metabolic process leukocyte migration positive regulation of transcription by RNA polymerase II biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 159296 18089 Ensembl ENSG00000119919 ENSMUSG00000044220 UniProt Q8TAU0 P97334 RefSeq (mRNA) NM_145285 NM_008699 RefSeq (protein) NP_660328 NP_032725 Location (UCSC) Chr 10: 99.53 – 99.54 Mb Chr 19: 43.6 – 43.6 Mb PubMed search [3] [4]
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NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.^[7]