NLK

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene.^[5][6][7] Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophila ortholog of the mammalian NLK gene.^[8] This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized.^[9]

AliasesNLK, nemo like kinase

External IDsOMIM: 609476; MGI: 1201387; HomoloGene: 88836; GeneCards: NLK; OMA:NLK - orthologs

Chr.Chromosome 17 (human)^[1]

End28,196,381 bp^[1]

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NLK
Identifiers
Aliases	NLK, nemo like kinase
External IDs	OMIM: 609476; MGI: 1201387; HomoloGene: 88836; GeneCards: NLK; OMA:NLK - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,041,737 bp[1] End 28,196,381 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 78,457,994 bp[2] End 78,588,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell retinal pigment epithelium primary visual cortex parietal lobe superior frontal gyrus postcentral gyrus entorhinal cortex internal globus pallidus Top expressed in Rostral migratory stream retinal pigment epithelium pineal gland prefrontal cortex medial ganglionic eminence habenula olfactory tubercle substantia nigra cumulus cell stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding transcription factor binding metal ion binding kinase activity protein binding ubiquitin protein ligase binding protein serine/threonine kinase activity SH2 domain binding ATP binding protein kinase activity magnesium ion binding MAP kinase activity Cellular component cytosol nucleoplasm nucleus cytoplasm Biological process phosphorylation protein stabilization Wnt signaling pathway transcription, DNA-templated MAPK cascade protein autophosphorylation transforming growth factor beta receptor signaling pathway Wnt signaling pathway, calcium modulating pathway regulation of transcription, DNA-templated negative regulation of Wnt signaling pathway protein phosphorylation peptidyl-threonine phosphorylation regulation of gene expression serine phosphorylation of STAT protein intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51701 18099 Ensembl ENSG00000087095 ENSMUSG00000017376 UniProt Q9UBE8 O54949 RefSeq (mRNA) NM_016231 NM_008702 RefSeq (protein) NP_057315 NP_032728 Location (UCSC) Chr 17: 28.04 – 28.2 Mb Chr 11: 78.46 – 78.59 Mb PubMed search [3] [4]
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