NLRP5

NLRP5
Identifiers
Aliases	NLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDs	OMIM: 609658; MGI: 1345193; HomoloGene: 65105; GeneCards: NLRP5; OMA:NLRP5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,061,810 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	23,141,347 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; gonad; ; endometrium; ; gastric mucosa; ; anterior pituitary; ; ovary; ; right ovary; ; myeloid leukocyte; ; monocyte;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; egg cell; ; ovary; ; morula; ; fossa; ; seminiferous tubule; ; spermatid; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding;
Cellular component	cytoplasm; nucleolus; mitochondrion; nucleus;
Biological process	neuron death;
	Sources:Amigo / QuickGO
Orthologs
	126206
	23968
	ENSG00000171487
	ENSMUSG00000015721
	P59047
	Q9R1M5
	NM_153447
	NM_001039143; NM_011860; NM_001305857
	NP_703148
	NP_001034232; NP_001292786; NP_035990
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.^[5]^[6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.