NLRP6

NLRP6
Identifiers
Aliases	NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDs	OMIM: 609650; MGI: 2141990; HomoloGene: 15881; GeneCards: NLRP6; OMA:NLRP6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	285,388 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,509,105 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; right lobe of liver; ; spleen; ; appendix; ; duodenum; ; left uterine tube; ; right lung; ; monocyte; ; lymph node;
	Top expressed in
	Paneth cell; ; jejunum; ; crypt of lieberkuhn of small intestine; ; left lobe of liver; ; duodenum; ; colon; ; ileum; ; right kidney; ; intestinal villus; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; vasopressin receptor activity; ATP binding;
Cellular component	cytoplasm; nuclear membrane; membrane; plasma membrane; inflammasome complex; nucleus;
Biological process	response to bacterium; immune system process; wound healing; regulation of mucus secretion; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of immune response; regulation of autophagy; negative regulation of toll-like receptor signaling pathway; negative regulation of inflammatory response to antigenic stimulus; regulation of inflammatory response; negative regulation of MAPK cascade; negative regulation of ERK1 and ERK2 cascade; innate immune response; inflammatory response; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	171389
	101613
	ENSG00000174885
	ENSMUSG00000038745
	P59044
	Q91WS2
	NM_001276700; NM_138329
	NM_001081389; NM_133946
	NP_001263629; NP_612202
	NP_598707
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.^[5]