NM-2-AI
Chemical compound
From Wikipedia, the free encyclopedia
NM-2-AI, or NM2AI, also known as N-methyl-2-aminoindane, is a stimulant of the 2-aminoindane family that has been sold online as a designer drug.[1] It is a rigid analogue of methamphetamine.[2][3] NM-2-AI acts as a selective norepinephrine releasing agent, but also has affinity for several monoamine receptors.[4][5]
- None
- DE: NpSG (Industrial and scientific use only)
- UK: Under Psychoactive Substances Act
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| Other names | NM2AI; N-Methyl-2-aminoindane; N-Methyl-2-AI; N-Methyl-AI; AM-80; Methaminoindan; Methoaminoindane |
| Drug class | Norepinephrine releasing agent; Stimulant |
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| Formula | C10H13N |
| Molar mass | 147.221 g·mol−1 |
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Pharmacology
Pharmacodynamics
NM-2-AI acts as a highly selective norepinephrine reuptake inhibitor and releasing agent in vitro and does not release serotonin or dopamine even at very high concentrations (100 μM).[4]
NM-2AI has high affinity (2.4 μM IC50) as a norepinephrine reuptake inhibitor but also has affinity as a TAAR1 receptor agonist (3.3 μM EC50), an Alpha-2A adrenergic receptor agonist (0.49 μM Ki) and as a binding agent at the 5-HT1A (3.6 μM Ki) and 5-HT2A (5.4 μM Ki) receptors.[5][4][6]
Pharmacokinetics
Metabolism
Scientists performed a study on NM-2-AI metabolism in silico and in vivo, in order to identify the main metabolites to be screened in the different biological samples. They performed the in silico metabolism prediction of NM-2-AI using MetaSiteTM software and subsequently verified the presence of metabolites in the blood, urine and hair of mice after NM-2-AI administration. LC-HRMS analysis identified seven main metabolites in the urine. They were identified, by their accurate masses and fragmentation patterns, as 2-aminoindane (2AI), two hydroxy-2-AI and four hydroxy-NM-2-AI; one of the hydroxy-NM-2-AI and one of the hydroxy-2-AI underwent also to conjugation. NM-2-AI and 2-AI were also detected by LC-HRMS in the hair and blood [7]