NOX1

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.^[5]

AliasesNOX1, GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1, NOH-1L

External IDsOMIM: 300225; MGI: 2450016; HomoloGene: 48495; GeneCards: NOX1; OMA:NOX1 - orthologs

Chr.X chromosome (human)^[1]

End100,874,359 bp^[1]

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NOX1
Identifiers
Aliases	NOX1, GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1, NOH-1L
External IDs	OMIM: 300225; MGI: 2450016; HomoloGene: 48495; GeneCards: NOX1; OMA:NOX1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 100,843,324 bp[1] End 100,874,359 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X 55.69 cM|X E3 Start 132,987,170 bp[2] End 133,122,705 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of sigmoid colon mucosa of transverse colon mucosa of ileum epithelium of colon testicle buccal mucosa cell pancreatic ductal cell gonad appendix Top expressed in ileum duodenum colon jejunum secondary oocyte embryo dentate gyrus of hippocampal formation granule cell primary oocyte zygote ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding voltage-gated ion channel activity protein binding NADP binding oxidoreductase activity superoxide-generating NAD(P)H oxidase activity Cellular component cytoplasm integral component of membrane endosome cell projection membrane plasma membrane cell junction NADPH oxidase complex early endosome Biological process cellular stress response to acidic pH NADP metabolic process intracellular pH elevation cellular response to hyperoxia regulation of ion transmembrane transport extracellular matrix organization positive regulation of JNK cascade oxygen metabolic process ion transport positive regulation of integrin biosynthetic process regulation of blood pressure respiratory burst hydrogen peroxide metabolic process angiogenesis positive regulation of cell population proliferation positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of vascular endothelial growth factor production inflammatory response regulation of systemic arterial blood pressure by renin-angiotensin cell migration signal transduction positive regulation of smooth muscle cell proliferation positive regulation of MAPK cascade ion transmembrane transport superoxide anion generation defense response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27035 237038 Ensembl ENSG00000007952 ENSMUSG00000031257 UniProt Q9Y5S8 Q8CIZ9 RefSeq (mRNA) NM_013955 NM_001271815 NM_007052 NM_013954 NM_172203 RefSeq (protein) NP_001258744 NP_008983 NP_039249 NP_757340 Location (UCSC) Chr X: 100.84 – 100.87 Mb Chr X: 132.99 – 133.12 Mb PubMed search [3] [4]
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NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.^[6]