Neuropeptides B/W receptor 2

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.^[3]

AliasesNPBWR2, GPR8, Neuropeptides B/W receptor 2, neuropeptides B and W receptor 2

External IDsOMIM: 600731; HomoloGene: 128565; GeneCards: NPBWR2; OMA:NPBWR2 - orthologs

Chr.Chromosome 20 (human)^[1]

End64,107,565 bp^[1]

Quick facts NPBWR2, Identifiers ...

NPBWR2
Identifiers
Aliases	NPBWR2, GPR8, Neuropeptides B/W receptor 2, neuropeptides B and W receptor 2
External IDs	OMIM: 600731; HomoloGene: 128565; GeneCards: NPBWR2; OMA:NPBWR2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,103,802 bp[1] End 64,107,565 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 right frontal lobe pituitary gland anterior pituitary anterior cingulate cortex adrenal gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled opioid receptor activity neuropeptide binding protein binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity peptide binding Cellular component integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled opioid receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2832 n/a Ensembl ENSG00000125522 ENSG00000277339 n/a UniProt P48146 n/a RefSeq (mRNA) NM_005286 n/a RefSeq (protein) NP_005277 n/a Location (UCSC) Chr 20: 64.1 – 64.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Close

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.^[3]