NPM3

Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene.^[5][6]

AliasesNPM3, PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3

External IDsOMIM: 606456; MGI: 894653; HomoloGene: 5083; GeneCards: NPM3; OMA:NPM3 - orthologs

Chr.Chromosome 10 (human)^[1]

End101,783,413 bp^[1]

Quick facts Identifiers, Aliases ...

NPM3
Identifiers
Aliases	NPM3, PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3
External IDs	OMIM: 606456; MGI: 894653; HomoloGene: 5083; GeneCards: NPM3; OMA:NPM3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.32 Start 101,781,325 bp[1] End 101,783,413 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 38.75 cM Start 45,736,173 bp[2] End 45,738,030 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte stromal cell of endometrium secondary oocyte gonad body of pancreas mucosa of transverse colon islet of Langerhans left adrenal cortex right adrenal gland right adrenal cortex Top expressed in epiblast spermatocyte thymus embryo yolk sac testicle lens ileum spermatid ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding chromatin binding histone binding Cellular component nucleus nucleolus cytosol actin cytoskeleton nucleoplasm cytoplasm Biological process rRNA processing rRNA transcription chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10360 18150 Ensembl ENSG00000107833 ENSMUSG00000056209 UniProt O75607 Q9CPP0 RefSeq (mRNA) NM_006993 NM_008723 RefSeq (protein) NP_008924 NP_032749 Location (UCSC) Chr 10: 101.78 – 101.78 Mb Chr 19: 45.74 – 45.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones.^[6]