COUP-TFI

NR2F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBL
Identifiers
Aliases	NR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDs	OMIM: 132890; MGI: 1352451; HomoloGene: 21158; GeneCards: NR2F1; OMA:NR2F1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	93,594,611 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	78,347,876 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; optic nerve; ; seminal vesicula; ; trigeminal ganglion; ; left uterine tube; ; germinal epithelium; ; ganglionic eminence; ; parietal pleura; ; lower lobe of lung; ; primary visual cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; lateral geniculate nucleus; ; anterior amygdaloid area; ; barrel cortex; ; medial dorsal nucleus; ; ventricular zone; ; vas deferens; ; saccule; ; ciliary body; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; steroid hormone receptor activity; sequence-specific DNA binding; transcription coactivator activity; DNA binding; nuclear receptor activity; zinc ion binding; protein binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; retinoic acid-responsive element binding;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; signal transduction; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; positive regulation of nucleic acid-templated transcription; nervous system development; negative regulation of neuron projection development; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7025
	13865
	ENSG00000175745
	ENSMUSG00000069171
	P10589
	Q60632
	NM_005654
	NM_010151; NM_001347538; NM_001347539
	NP_005645
NP_001334467; NP_001334468; NP_034281; NP_001390702; NP_001390704;
	NP_001390706
	Wikidata
View/Edit Human	View/Edit Mouse

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.^[5]^[6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.