Neuregulin 4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[5][6][7]

Quick facts NRG4, Identifiers ...
NRG4
Identifiers
AliasesNRG4, HRG4, neuregulin 4
External IDsOMIM: 610894; MGI: 1933833; HomoloGene: 12921; GeneCards: NRG4; OMA:NRG4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138573

NM_032002

RefSeq (protein)

NP_612640

NP_114391

Location (UCSC)Chr 15: 75.94 – 76.06 MbChr 9: 55.13 – 55.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[7]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[8]

References

Further reading

Related Articles

Wikiwand AI