NSFL1C

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesNSFL1C, P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor

External IDsOMIM: 606610; MGI: 3042273; HomoloGene: 41114; GeneCards: NSFL1C; OMA:NSFL1C - orthologs

Chr.Chromosome 20 (human)^[1]

Quick facts Available structures, PDB ...

NSFL1C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SS6
Identifiers
Aliases	NSFL1C, P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor
External IDs	OMIM: 606610; MGI: 3042273; HomoloGene: 41114; GeneCards: NSFL1C; OMA:NSFL1C - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 1,442,162 bp[1] End 1,473,842 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 151,336,102 bp[2] End 151,353,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland gastrocnemius muscle left adrenal cortex skin of leg tibialis anterior muscle skin of abdomen retinal pigment epithelium monocyte Top expressed in tail of embryo lens neural layer of retina genital tubercle neural tube hypothalamus yolk sac olfactory bulb ventricular zone ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding ubiquitin binding protein binding phospholipid binding protein phosphatase regulator activity ATPase binding Cellular component Golgi stack plasma membrane Golgi apparatus intermediate filament cytoskeleton VCP-NSFL1C complex nucleus nucleoplasm chromosome cytosol spindle pole centrosome cytoplasm microtubule organizing center cytoskeleton Biological process membrane fusion nuclear membrane reassembly Golgi organization proteasome-mediated ubiquitin-dependent protein catabolic process autophagosome assembly regulation of phosphoprotein phosphatase activity establishment of mitotic spindle orientation positive regulation of mitotic centrosome separation negative regulation of protein localization to centrosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55968 386649 Ensembl ENSG00000088833 ENSMUSG00000027455 UniProt Q9UNZ2 Q9CZ44 RefSeq (mRNA) NM_001206736 NM_016143 NM_018839 NM_182483 NM_001291074 NM_198326 RefSeq (protein) NP_001193665 NP_057227 NP_061327 NP_001278003 NP_938085 Location (UCSC) Chr 20: 1.44 – 1.47 Mb Chr 2: 151.34 – 151.35 Mb PubMed search [3] [4]
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N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.^[6]