Neurotrophin-4

NTF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662; MGI: 97381; HomoloGene: 4503; GeneCards: NTF4; OMA:NTF4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,065,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,066,603 bp
RNA expression pattern
	Top expressed in
	testicle; ; skeletal muscle tissue; ; skin of abdomen; ; muscle of thigh; ; skin of leg; ; gonad; ; prostate; ; mucosa of esophagus; ; gastrocnemius muscle; ; minor salivary glands;
	Top expressed in
	hand; ; Gonadal ridge; ; molar; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; upper arm; ; knee joint; ; triceps brachii muscle; ; urothelium; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	neurotrophin p75 receptor binding; signaling receptor binding; protein binding; growth factor activity;
Cellular component	cytoplasmic vesicle; extracellular region; extracellular space; synaptic vesicle; axon; dendrite;
Biological process	negative regulation of neuron apoptotic process; regulation of neuron differentiation; adult locomotory behavior; sensory organ boundary specification; cell-cell signaling; neuron projection morphogenesis; innervation; negative regulation of cell death; long-term memory; taste bud development; mechanoreceptor differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; ganglion mother cell fate determination; epidermis development; regulation of signaling receptor activity; activation of phospholipase C activity; neurotrophin TRK receptor signaling pathway; peripheral nervous system development; memory; nerve development; nerve growth factor signaling pathway; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	4909
	78405
	ENSG00000225950
	ENSMUSG00000074121
	P34130
	Q80VU4
	NM_006179; NM_001395489
	NM_198190
	NP_006170
	NP_937833
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrophin-4 (NT-4),^[5] also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[6] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.^[7]^[8] NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al^[9]