NUDCD3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesNUDCD3, NudCL, NudC domain containing 3
Quick facts Available structures, PDB ...
NUDCD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDCD3, NudCL, NudC domain containing 3
External IDsOMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015332

NM_173748
NM_001363446

RefSeq (protein)

NP_056147

NP_776109
NP_001350375

Location (UCSC)Chr 7: 44.38 – 44.49 MbChr 11: 6.06 – 6.15 Mb
PubMed search[3][4]
Wikidata
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Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.[5]

References

Further reading

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