NUDT12

Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.^[5][6]

AliasesNUDT12, nudix hydrolase 12

External IDsOMIM: 609232; MGI: 1915243; HomoloGene: 44188; GeneCards: NUDT12; OMA:NUDT12 - orthologs

Chr.Chromosome 5 (human)^[1]

End103,562,790 bp^[1]

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NUDT12
Identifiers
Aliases	NUDT12, nudix hydrolase 12
External IDs	OMIM: 609232; MGI: 1915243; HomoloGene: 44188; GeneCards: NUDT12; OMA:NUDT12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q21.2 Start 103,548,855 bp[1] End 103,562,790 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 59,306,613 bp[2] End 59,320,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans jejunal mucosa rectum Achilles tendon testicle body of pancreas right adrenal cortex vastus lateralis muscle mucosa of paranasal sinus left adrenal gland Top expressed in left lobe of liver brown adipose tissue intercostal muscle human kidney Epithelium of choroid plexus right kidney lobe of prostate adrenal gland white adipose tissue proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function NAD+ diphosphatase activity protein binding hydrolase activity metal ion binding NADH pyrophosphatase activity Cellular component cytoplasm peroxisome nucleus peroxisomal matrix cytosol Biological process NAD catabolic process NADP catabolic process NAD biosynthesis via nicotinamide riboside salvage pathway NADH metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83594 67993 Ensembl ENSG00000112874 ENSMUSG00000024228 UniProt Q9BQG2 Q9DCN1 RefSeq (mRNA) NM_001300741 NM_031438 NM_026497 NM_001368393 RefSeq (protein) NP_001287670 NP_113626 NP_080773 NP_001355322 Location (UCSC) Chr 5: 103.55 – 103.56 Mb Chr 17: 59.31 – 59.32 Mb PubMed search [3] [4]
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Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors.

Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003).[supplied by OMIM]^[6]