NUDT21

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene.^[5][6] It belongs to the Nudix family of hydrolases.

PDBOrtholog search: PDBe RCSB

AliasesNUDT21, CFIM25, CPSF5, nudix hydrolase 21

External IDsOMIM: 604978; MGI: 1915469; HomoloGene: 5090; GeneCards: NUDT21; OMA:NUDT21 - orthologs

Chr.Chromosome 16 (human)^[1]

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NUDT21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CL3, 2J8Q, 3BAP, 3BHO, 3MDG, 3MDI, 3N9U, 3P5T, 3P6Y, 3Q2S, 3Q2T
Identifiers
Aliases	NUDT21, CFIM25, CPSF5, nudix hydrolase 21
External IDs	OMIM: 604978; MGI: 1915469; HomoloGene: 5090; GeneCards: NUDT21; OMA:NUDT21 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,429,133 bp[1] End 56,452,199 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 94,742,124 bp[2] End 94,763,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence ventricular zone pons caput epididymis left testis germinal epithelium superior vestibular nucleus Achilles tendon right testis Top expressed in superior cervical ganglion spermatocyte ventricular zone spermatid embryo yolk sac hand embryo ganglionic eminence tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity histone deacetylase binding protein binding mRNA binding hydrolase activity RNA binding identical protein binding chromatin binding mRNA 3'-UTR AU-rich region binding Cellular component paraspeckles centrosome nucleoplasm microtubule organizing center mRNA cleavage factor complex nucleus nuclear body cytoplasm mRNA cleavage and polyadenylation specificity factor complex Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription protein tetramerization mRNA 3'-end processing mRNA polyadenylation mRNA processing posttranscriptional regulation of gene expression cell differentiation positive regulation of mRNA cleavage protein heterotetramerization pre-mRNA cleavage required for polyadenylation mRNA alternative polyadenylation positive regulation of mRNA polyadenylation messenger ribonucleoprotein complex assembly positive regulation of stem cell differentiation positive regulation of pro-B cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11051 68219 Ensembl ENSG00000167005 ENSMUSG00000031754 UniProt O43809 Q9CQF3 RefSeq (mRNA) NM_007006 NM_026623 RefSeq (protein) NP_008937 NP_080899 Location (UCSC) Chr 16: 56.43 – 56.45 Mb Chr 8: 94.74 – 94.76 Mb PubMed search [3] [4]
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The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.^[7] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.^[6]