NUF2

NUF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VE7, 3IZ0
Identifiers
Aliases	NUF2, CDCA1, CT106, NUF2R, NDC80 kinetochore complex component, NDC80 kinetochore complex component NUF2 component of NDC80 kinetochore complex
External IDs	OMIM: 611772; MGI: 1914227; HomoloGene: 40205; GeneCards: NUF2; OMA:NUF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	163,355,764 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	169,359,033 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; thymus; ; gonad; ; right testis; ; left testis; ; testicle; ; sperm; ; bone marrow; ; trabecular bone;
	Top expressed in
	spermatocyte; ; zygote; ; spermatid; ; tail of embryo; ; secondary oocyte; ; primary oocyte; ; ventricular zone; ; genital tubercle; ; dermis; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function; protein-containing complex binding;
Cellular component	cytosol; nucleus; membrane; chromosome, centromeric region; chromosome; kinetochore; Ndc80 complex;
Biological process	cell division; cell cycle; chromosome segregation; sister chromatid cohesion; mitotic cell cycle; mitotic spindle organization; meiotic chromosome segregation; attachment of mitotic spindle microtubules to kinetochore; kinetochore organization;
	Sources:Amigo / QuickGO
Orthologs
	83540
	66977
	ENSG00000143228
	ENSMUSG00000026683
	Q9BZD4
	Q99P69
	NM_031423; NM_145697
	NM_023284; NM_001355159
	NP_113611; NP_663735
	NP_075773; NP_001342088
	Wikidata
View/Edit Human	View/Edit Mouse

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.^[5]^[6]^[7]

PDBOrtholog search: PDBe RCSB

AliasesNUF2, CDCA1, CT106, NUF2R, NDC80 kinetochore complex component, NDC80 kinetochore complex component NUF2 component of NDC80 kinetochore complex

External IDsOMIM: 611772; MGI: 1914227; HomoloGene: 40205; GeneCards: NUF2; OMA:NUF2 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts Available structures, PDB ...

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This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.

The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.^[7]

[5]

[6]

[7]

[1]

[2]

[3]

[4]

NUF2

References

Further reading

Related Articles

Related Articles

"The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation"

"hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension"

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"

"Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites"

"Phosphoproteome analysis of the human mitotic spindle"

"Large-scale mapping of human protein-protein interactions by mass spectrometry"