Nucleoporin 50

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesNUP50, NPAP60, NPAP60L, nucleoporin 50kDa, nucleoporin 50

External IDsOMIM: 604646; MGI: 1351502; HomoloGene: 5190; GeneCards: NUP50; OMA:NUP50 - orthologs

Chr.Chromosome 22 (human)^[1]

Quick facts NUP50, Available structures ...

NUP50
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EC1, 3TJ3
Identifiers
Aliases	NUP50, NPAP60, NPAP60L, nucleoporin 50kDa, nucleoporin 50
External IDs	OMIM: 604646; MGI: 1351502; HomoloGene: 5190; GeneCards: NUP50; OMA:NUP50 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 45,163,925 bp[1] End 45,188,017 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E2|15 40.25 cM Start 84,807,612 bp[2] End 84,827,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx nasal epithelium mucosa of paranasal sinus bone marrow bone marrow cell endothelial cell trabecular bone Epithelium of choroid plexus blood sperm Top expressed in Ileal epithelium zygote seminiferous tubule primitive streak spermatid secondary oocyte epiblast tail of embryo genital tubercle yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component nuclear membrane membrane nucleoplasm nucleus intracellular membrane-bounded organelle nuclear pore cytoplasm centrosome host cell Biological process mRNA transport intracellular transport protein transport viral process protein import into nucleus mRNA export from nucleus positive regulation of GTPase activity regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10762 18141 Ensembl ENSG00000093000 ENSMUSG00000016619 UniProt Q9UKX7 Q9JIH2 RefSeq (mRNA) NM_007172 NM_153645 NM_153684 NM_016714 RefSeq (protein) NP_009103 NP_705931 NP_057923 Location (UCSC) Chr 22: 45.16 – 45.19 Mb Chr 15: 84.81 – 84.83 Mb PubMed search [3] [4]
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The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.^[6]