NXPH1

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.^[5][6]

AliasesNXPH1, NPH1, Nbla00697, neurexophilin 1

External IDsOMIM: 604639; MGI: 107492; HomoloGene: 8284; GeneCards: NXPH1; OMA:NXPH1 - orthologs

Chr.Chromosome 7 (human)^[1]

End8,752,961 bp^[1]

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NXPH1
Identifiers
Aliases	NXPH1, NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639; MGI: 107492; HomoloGene: 8284; GeneCards: NXPH1; OMA:NXPH1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.3 Start 8,433,609 bp[1] End 8,752,961 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 8,948,431 bp[2] End 9,249,032 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex endothelial cell secondary oocyte prefrontal cortex testicle left adrenal gland left adrenal cortex hypothalamus cingulate gyrus anterior cingulate cortex Top expressed in lateral septal nucleus medial dorsal nucleus dorsomedial hypothalamic nucleus ventral tegmental area anterior amygdaloid area dorsal tegmental nucleus medial vestibular nucleus habenula lumbar subsegment of spinal cord ventromedial nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 30010 18231 Ensembl ENSG00000122584 ENSMUSG00000046178 UniProt P58417 Q61200 RefSeq (mRNA) NM_152745 NM_008751 RefSeq (protein) NP_689958 NP_032777 Location (UCSC) Chr 7: 8.43 – 8.75 Mb Chr 6: 8.95 – 9.25 Mb PubMed search [3] [4]
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This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.^[6]