Methaniazide/thioacetazone

Methaniazide/thioacetazone, sold under the brand name Neothetazone, is an antibiotic combination of methaniazide (neotizide) and thioacetazone that is or was very commonly used in the treatment of tuberculosis.^[1] It has been implicated as a cause of gigantomastia in a single 1970 case report,^[2][3] and, along with D-penicilliamine, bucillamine, ciclosporin, and indinavir, is one of the only drugs to have been associated with gigantomastia.^[2][3][4][5]