NEUROD2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[5][6]

AliasesNEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
End39,609,777 bp[1]
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NEUROD2
Identifiers
AliasesNEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
External IDsOMIM: 601725; MGI: 107755; HomoloGene: 4489; GeneCards: NEUROD2; OMA:NEUROD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006160

NM_010895

RefSeq (protein)

NP_006151

NP_035025

Location (UCSC)Chr 17: 39.6 – 39.61 MbChr 11: 98.22 – 98.22 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[6]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[7]

References

Further reading

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