Hepatitis C virus nonstructural protein 3
From Wikipedia, the free encyclopedia
Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is the 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease.[1][2] The C-terminal two-thirds of the protein also acts as a helicase and nucleoside triphosphatase.[3] The first (N-terminal) 180 amino acids of NS3 have an additional role as cofactor domains for the NS2 protein.[4]
HCV genome | |||||||
| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Organism | |||||||
| Symbol | NS3 | ||||||
| Entrez | 951475 | ||||||
| RefSeq (Prot) | NP_803144.1 | ||||||
| UniProt | Q91RS4 | ||||||
| Other data | |||||||
| Chromosome | Genomic: 0 - 0 Mb | ||||||
| |||||||
See also
- Boceprevir, sovaprevir, paritaprevir and telaprevir - drugs targeting this protein[5]
