Norbinaltorphimine

Norbinaltorphimine
Clinical data
ATC code	none;
Legal status
Legal status	US: Schedule II (derivative of noroxymorphone);
Identifiers
	IUPAC name 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino-7,7'-bimorphinan-3,4',14,14'-tetrol;
CAS Number	105618-26-6 ;
PubChem CID	3034416;
IUPHAR/BPS	1642;
ChemSpider	21248347 ;
UNII	36OOQ86QM1;
PDB ligand	A1AD6 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID90897163 ;
Chemical and physical data
Formula	C40H43N3O6
Molar mass	661.799 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1;
	InChI InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1 ; Key:APSUXPSYBJVPPS-YAUKWVCOSA-N ;
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Norbinaltorphimine (nor-BNI or nBNI) is an opioid receptor antagonist used in scientific research. It is a highly selective inverse agonist for the κ-opioid receptor.^[1]^[2] In animals, nor-BNI blocks the effects of κ-opioids^[3]^[4] with a slow onset and an exceptionally long duration of action (up to several months).^[5]^[6] It produces antidepressant-like^[7] and anxiolytic-like effects in animal models.^[8]