Nuclear mitotic apparatus protein 1

NUMA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RO2
Identifiers
Aliases	NUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDs	OMIM: 164009; MGI: 2443665; HomoloGene: 38150; GeneCards: NUMA1; OMA:NUMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,080,693 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,664,171 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of uterus; ; canal of the cervix; ; left ovary; ; right ovary; ; gastric mucosa; ; muscle layer of sigmoid colon; ; ectocervix; ; right lobe of thyroid gland; ; ventricular zone;
	Top expressed in
	genital tubercle; ; Rostral migratory stream; ; ventricular zone; ; vas deferens; ; neural layer of retina; ; cumulus cell; ; efferent ductule; ; Gonadal ridge; ; thymus; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; protein binding; microtubule binding; protein C-terminus binding; tubulin binding; phosphatidylinositol binding; microtubule plus-end binding; microtubule minus-end binding; dynein complex binding; disordered domain specific binding; lipid binding; protein domain specific binding; protein-containing complex binding;
Cellular component	extracellular exosome; spindle; mitotic spindle; chromosome; microtubule organizing center; Golgi membrane; apical part of cell; mitotic spindle astral microtubule; centrosome; microtubule; soma; dendrite; cytoskeleton; spindle microtubule; spindle pole; nucleus; cytoplasm; cytosol; nuclear matrix; extrinsic component of plasma membrane; spindle pole centrosome; microtubule plus-end; microtubule minus-end; cortical microtubule; microtubule bundle; mitotic spindle pole; cell cortex region; cytoplasmic microtubule bundle; mitotic spindle midzone; nucleoplasm; plasma membrane; cell cortex; membrane; lateral cell cortex; lateral plasma membrane; protein-containing complex;
Biological process	lung epithelial cell differentiation; cell cycle; cell division; meiosis; nucleus organization; establishment of mitotic spindle orientation; microtubule bundle formation; positive regulation of BMP signaling pathway; astral microtubule organization; positive regulation of microtubule polymerization; positive regulation of intracellular transport; positive regulation of keratinocyte differentiation; positive regulation of hair follicle development; positive regulation of chromosome segregation; anastral spindle assembly; regulation of mitotic spindle organization; regulation of metaphase plate congression; positive regulation of protein localization to spindle pole body; positive regulation of mitotic spindle elongation; positive regulation of protein localization to cell cortex; positive regulation of chromosome separation; positive regulation of spindle assembly; chromosome segregation;
	Sources:Amigo / QuickGO
Orthologs
	4926
	101706
	ENSG00000137497
	ENSMUSG00000066306
	Q14980; Q3SYK8
	E9Q7G0
	NM_001286561; NM_006185
	NM_133947
	NP_001273490; NP_006176; NP_006176.2
NP_598708; NP_001390473; NP_001390474; NP_001390475; NP_001390476;
	NP_001390477; NP_001390478; NP_001390479; NP_001390480; NP_001390481; NP_001390482
	Wikidata
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