Solute carrier organic anion transporter family member 1B1

SLCO1B1
Identifiers
Aliases	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDs	OMIM: 604843; MGI: 1351899; HomoloGene: 74575; GeneCards: SLCO1B1; OMA:SLCO1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,239,796 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	141,632,372 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; buccal mucosa cell; ; pancreatic ductal cell; ; gallbladder; ; renal cortex; ; cervix; ; canal of the cervix; ; mouth; ; haematopoietic system;
	Top expressed in
	left lobe of liver; ; embryo; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; primary visual cortex; ; proximal tubule; ; jejunum; ; thoracic diaphragm; ; pancreas; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity; bile acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; bile acid and bile salt transport; organic anion transport; thyroid hormone transport; sodium-independent organic anion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10599
	28253
	ENSG00000134538
	ENSMUSG00000030236
	Q9Y6L6
	Q9JJL3
	NM_006446
	NM_020495; NM_178235
	NP_006437
	NP_065241
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.^[5]^[6] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.^[7] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.^[8]