Solute carrier organic anion transporter family member 1B3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[5]
| SLCO1B3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.
Clinical significance
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[7]
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[7]
Substrates
Small molecules that are transported by SLCO1B3 include:[8]
- Amanitin
- Atrasentan
- Bilirubin
- Bosentan
- BQ-123
- Bromsulphthalein (BSP)
- CDCA-NBD
- Cholate (CA)
- Cholecystokinin octapeptide (CCK-8)
- Dehydroepiandroserone-3-sulfate (DHEAS)
- Deltorphin II
- Demethylphalloin
- Digoxin
- Docetaxel
- [D-penicillamine2,5]enkephalin (DPDPE)
- Enalapril
- Estradiol-17β-glucuronide 5–25
- Estrone-3-sulfate
- Fexofenadine
- Fluvastatin
- Fluo-3
- Glutathione (GSH)
- Glycocholate (GCA)
- Glycoursodeoxycholate (GUDCA)
- Irinotecan
- Leukotriene C4 (LTC4)
- Methotrexate
- Microcystin
- Monoglyucuronosyl
- Olmesartan
- Ouabain
- Paclitaxel
- Phalloidin
- Pitavastatin
- Rifampicin
- Ro 48-5033 (Bosentan metabolite)
- Rosuvastatin
- SN-38
- Taurocholate (TCA)
- Taurochenodeoxycholate (TCDCA)
- Taurodeoxycholate (TDCA)
- Tauroursodeoxycholate (TUDCA)
- Telmisartan
- Thyroxine (T4)
- TR-14035
- Triiodothyronine (T3)
- Valsartan
