OLA1

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene.^[5][6] Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP).^[5]

PDBOrtholog search: PDBe RCSB

AliasesOLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1

External IDsOMIM: 611175; MGI: 1914309; HomoloGene: 5361; GeneCards: OLA1; OMA:OLA1 - orthologs

Chr.Chromosome 2 (human)^[1]

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OLA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OHF
Identifiers
Aliases	OLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDs	OMIM: 611175; MGI: 1914309; HomoloGene: 5361; GeneCards: OLA1; OMA:OLA1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 174,072,447 bp[1] End 174,248,599 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,923,145 bp[2] End 73,049,268 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence lateral nuclear group of thalamus pons Brodmann area 23 gingival epithelium lactiferous duct parotid gland entorhinal cortex ventricular zone Top expressed in Paneth cell tail of embryo cumulus cell condyle ureter medial ganglionic eminence primitive streak epiblast barrel cortex hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding hydrolase activity metal ion binding ATP binding ATPase activity cadherin binding ribosome binding ribosomal large subunit binding Cellular component centrosome nucleolus extracellular exosome membrane nucleus extracellular region cytoplasm cytosol platelet alpha granule lumen Biological process ATP metabolic process platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29789 67059 Ensembl ENSG00000138430 ENSMUSG00000027108 UniProt Q9NTK5 Q9CZ30 RefSeq (mRNA) NM_013341 NM_001011708 NM_001328688 NM_025942 NM_030091 RefSeq (protein) NP_001011708 NP_001315617 NP_037473 NP_080218 NP_084367 Location (UCSC) Chr 2: 174.07 – 174.25 Mb Chr 2: 72.92 – 73.05 Mb PubMed search [3] [4]
Wikidata
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